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Standard investigations for thyrotoxicosis include blood tests for:

  • TSH; usually suppressed
  • T4; usually raised
  • +/- T3

Always check the patient’s full blood count (FBC) and consider:

  • Thyroid peroxidase Ab
  • Thyroid stimulating hormone receptor (TSHr) stimulating Ab
  • C-reactive protein

Some patients will also need :

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Standard investigations for thyrotoxicosis include blood tests for:

  • TSH; usually suppressed
  • T4; usually raised
  • +/- T3

Always check the patient’s full blood count (FBC) and consider:

  • Thyroid peroxidase Ab
  • Thyroid stimulating hormone receptor (TSHr) stimulating Ab
  • C-reactive protein

Some patients will also need :

  • A thyroid uptake scan in certain specific circumstances

It is exceptionally useful to:

  1. Assist with the differential diagnosis of any patient with biochemical thyrotoxicosis
  2. Identify a ‘hot’ or ‘hyperfunctioning’ nodule in the context of any patient with thyrotoxicosis or subclinical hyperthyroidism
  3. Detect retrosternal or ectopic functioning tissue

Fig 1 This is an Iodine-123 thyroid scan in a patient with Graves' disease. Tracer uptake is uniform throughout the gland
(Reproduced with permission from eMedicine.com)

Fig 2 This is an Iodine-123 scan in a patient with a palpable nodule in the right neck, a low serum level for thyrotropin, and a slightly elevated serum level of free triiodothyronine. The autonomously functioning (‘hot’) nodule is clearly seen and the image contrasts significantly with that in Fig 1
(Reproduced with permission from eMedicine.com)

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Standard investigations for thyrotoxicosis include blood tests for:

  • TSH; usually suppressed
  • T4; usually raised
  • +/- T3

Always check the patient’s full blood count (FBC) and consider:

  • Thyroid peroxidase Ab
  • Thyroid stimulating hormone receptor (TSHr) stimulating Ab
  • C-reactive protein

Some patients will also need :

Fig 3 Axial CT scan of a patient with congestive thyroid orbitopathy
(Reproduced with permission from eMedicine.com)